PMS: Advice for Everyone

Managing your health as a woman requires time, intuition, perseverance, science, and, in every case…thick skin.

Another challenge?

Most men in relationships don’t realize just how much they don’t know about women’s health. And it’s not just something that only affects her—when a woman isn’t feeling her best, it can have a ripple effect on the entire relationship.

It’s almost 2025, and it’s time for a change. 

Let’s bridge the gap in understanding and take action to support the women we care about. 

I’m thrilled to introduce Microdosing.com’s newest curator, Stephanie Karzon Abrams, Clin.Pharm, Neuropharmacologist, Consultant, and Advocate for psychedelic and plant medicine innovation. 

Stephanie is an expert in neurology, women's health, and plant medicines. She is passionate about innovative therapies and plant medicines, music, writing, and curating unique events that bring people together. She is excited to work on this project because she is dedicated to pushing the boundaries of innovation in health and wellness, with a deep belief in empowering individuals to take charge of their own health. A passionate advocate for the “right to try,” she supports plant medicine and psychedelic research not as a replacement for conventional therapies, but as an alternative when traditional approaches fall short or when individuals seek new paths to healing.

Stephanie, the founder of Beyond Consulting and leads diverse projects at the forefront of psychedelics and plant medicine. Some of her current projects include Modern Medicine Services, an integrative medicine and mental health clinic in Los Angeles and research directorship for the Microdosing Collective, a nonprofit advocating for education, harm reduction, and policy changes around safe, low-dose psychedelics. Stephanie is also touring The Chemistry of Joy, an event series co-created with Jane Garnett, LMFT, exploring neuroscience and neurochemistry, the importance of cultivating joy in our lives, and the transformative potential of psychedelics in healing and growth. Additionally, she actively writes, speaks, and conducts research studies on psychedelics, neurology, and women's health.

As a gift to the microdosing community, Stephanie has prepared a condensed supplement guide on managing the most common and debilitating women's health conditions + she gives practical advice for men to support the women in their lives during difficult times. (contact her on her website for a free first consult!)

So, whether you are a woman or just love them, you're in for a download you can't afford to miss. 

• Tip bookmark this issue so you can return to it as needed. Bonus points if you send it to a friend. 

Take it away, Steph…

From Steph

For women, the felt (somatic) experience of psychoactive or psychedelic substances can be deeply influenced by hormonal fluctuations, particularly by levels of estrogen and progesterone. 

These hormones interact with our serotonin system, which is central to producing the experience of most classical psychedelics. 

Timing in a woman’s cycle can bring significant shifts in hormone levels, often leading to deeper emotional or introspective moments. While these experiences may feel challenging at times, they carry immense power—hormonal fluctuations can be embraced as a source of insight, growth, and even creativity.

Women’s health conditions like PMDD & PME (forms of PMS), postpartum, and perimenopause are directly related to hormone levels and, for BILLIONS of women, affect both physical and emotional well-being frequently.

These conditions are often poorly managed by modern medicine, forcing women who suffer to seek out more effective solutions on their own.  

In today’s newsletter, we’ll discuss the timeless remedies for symptoms of typical women's health conditions and review practical guidance for men to support women in their lives during these difficult times. 

And yes, my list of remedies DOES include microdosing. 🙂

Microdosing for PMDD and PME: What’s the Buzz?

Premenstrual Dysphoric Disorder (PMDD) and Premenstrual Exacerbation (PME) are severe forms of PMS that can significantly impact mood, energy, and daily life.

The University of Auckland in New Zealand is exploring how microdosing psychedelics might help stabilize mood swings and ease anxiety related to these conditions. For anyone who is interested in participating in the Auckland study,
📨 email: [email protected]

This research is significant because it is one of the first major studies examining the effects of microdosing LSD on PMS and PMDD specifically. 

If the results are positive, microdosing may become an accessible solution for women dealing with these conditions, offering new hope for managing symptoms that traditional treatments often fail.

As of now, early studies suggest that microdosing may offer women greater balance without the full intensity of traditional psychedelic therapy.

Medicinal Plants: A Natural Ally for Hormonal Balance 

Until the psychedelic research catches up, women must face breaking the law to use psychedelics in most places.

I wholeheartedly acknowledge and celebrate Western medicine and hormone therapies that truly help women, offering relief and healing. My mission is to address the gaps in choice and access. When conventional therapies fall short or when women seek alternatives, the options can be frustratingly limited. 

This is the real issue: we need a broader range of solutions and the "right to try" treatments that align with our individual needs and values. Women deserve nothing less than the full spectrum of care.

For women dealing with period pain, disruptive premenstrual symptoms, or the rollercoaster of perimenopause—hot flashes, mood swings, night sweats—relief isn’t just a luxury, it’s a necessity. These symptoms can be so overwhelming that they disrupt daily life. 

Many choose to work with other medicinal plants to balance hormones and manage symptoms naturally; remedies have been used for millennia and offer gentle, effective relief. 

However, don't be mistaken; natural herbal remedies can be powerful allies in health care.

I invite you to remember that just because they are legal doesn't mean they are ineffective; it probably just means pharmaceutical companies couldn't find ways to make money with them. 

Note: The advice I give below is general, and it's always best to consult with a professional to find specific advice that fits your unique situation. You can contact me via my website for more information. 

Supportive Plants:

Estrogen Enhances Psychedelic Effects in Women

Estrogen significantly influences how psychedelics like psilocybin and LSD affect the brain by modulating serotonin—a neurotransmitter essential for mood and cognition. 

Elevated estrogen levels at specific points in the menstrual cycle increase serotonin production, inhibit its breakdown, and enhance receptor sensitivity. The combined effect results in greater serotonin availability and heightened brain responsiveness, potentially amplifying the effects of psychedelics and promoting neuroplasticity.

Throughout the menstrual cycle, estrogen levels fluctuate, leading to varying psychedelic experiences:

• Mid-Follicular Phase: Estrogen levels rise, potentially intensifying the effects of serotonergic psychedelics.

• Post-Ovulation: Estrogen levels drop, which may reduce the intensity of psychedelic effects.

• Mid-Luteal Phase: A secondary rise in estrogen occurs, possibly enhancing psychedelic responsiveness again.

Life stages such as puberty, pregnancy, and menopause involve significant hormonal shifts, influencing the efficacy and subjective experience of psychedelics. 

This variability underscores the importance of researching how classical psychedelics can influence hormonal changes, especially when symptoms like pain, headaches, and severe mood fluctuations become challenging.

For further reading:

• Psilocybin shows promise in supporting symptoms of PMDD

• Using Psychedelics for Pre Menstrual Pain

• Sex-Dependent Differences in Response to Psychedelics

Ketamine for PMDD and Postpartum - Right Now! 

PMDD and postpartum depression are significant challenges for many women, often linked to hormonal fluctuations and neurotransmitter imbalances. 

Current treatments for PMDD, such as selective serotonin reuptake inhibitors (SSRIs), have a low rate of success, indicating a need for alternative or adjunctive therapies.

Ketamine, traditionally used as an anesthetic, has emerged as a potential treatment option for these conditions due to its rapid antidepressant effects and unique mechanisms of action.

Ketamine’s Role in PMDD:

PMDD symptoms are closely associated with declining estrogen levels during the luteal phase of the menstrual cycle. Ketamine has been observed to interact with estrogen receptors and may influence estrogen levels, potentially mitigating PMDD symptoms. 

Additionally, low glutamate levels in certain brain regions are linked to depression. Ketamine enhances glutamate transmission, a key factor in its antidepressant effects. 

Administering ketamine at the onset of PMDD symptoms could alleviate associated signs and symptoms. 

Ketamine’s Role in Postpartum Depression:

Postpartum depression affects a significant number of new mothers. A study involving 654 women undergoing cesarean sections administered a single dose of ketamine (0.5 mg/kg) 10 minutes after childbirth. 

The results showed a notable reduction in the incidence of postpartum blues and depression among the ketamine group compared to those receiving standard postpartum care. 

Ketamine’s rapid onset of action and short half-life make it a promising option for relief of postpartum depression symptoms.

Ketamine and Breastfeeding:

For postpartum women who are breastfeeding, the use of ketamine requires careful consideration. 

While ketamine is metabolized and eliminated from the body relatively quickly, it is recommended to avoid breastfeeding for 12 hours after administration to ensure the drug is adequately cleared from the system. This precaution helps minimize any potential exposure to the nursing infant.

Ketamine and Breastfeeding

Ketamine and Lactation

How Men Can Be Supportive:

Being supportive of a woman experiencing PMS or perimenopause is about empathy and action. 

Here are a few simple but meaningful ways men can help:

1. Show your care by taking an active interest in understanding women’s health. Explore the benefits of treatments like microdosing or medicinal plants, and dive into the fascinating world of menstrual cycles—it’s an eye-opening journey with so much to learn and practice.

Start Here:

• Phases of the Menstrual Cycle by Perelel Health

• Insights from Dr. Suzanne

• Explore Hystelica

• Menstrual Health by GUUD Woman

2. Be Patient and Present: Hormonal fluctuations can cause mood swings, irritability, and fatigue. Show patience and offer a listening ear without judgment. Sometimes, simply being present and validating her experience is the most valuable support. Don't offer solutions; encourage and just allow her to share herself without worry of judgment.  

3. Physical touch: Non-sexual physical touch from a partner can be highly beneficial, offering both emotional and physical relief. This form of comfort not only promotes relaxation but also strengthens your bond. 

4. Encourage Self-Care: Encourage healthy routines incorporating these medicinal plants and practices. Offer to prepare a cup of medicinal tea or remind her to take her evening supplements. Simple gestures can show that you care about her well-being.

Men can also be intentional about their psychedelic use to become better partners. 

Psychedelics can be uniquely transformational by facilitating a break from traditional societal expectations and emotional barriers; many Men find that, once becoming open to it, psychedelics help in accessing and expressing repressed emotions, promoting psychological flexibility, and enhancing empathy and connectedness. 

As a woman, I know firsthand how complex and deeply personal our health journeys can be. These challenges don’t just affect us—they ripple into our relationships, families, and communities. 

I deeply respect the support and efficacy that Western medicine and traditional hormone therapies provide for women. However, if these treatments aren't meeting your needs or if you're simply seeking alternative options, you deserve the freedom to explore them. This begins with building a strong foundation of education and knowledge, empowering you to make informed and safe decisions about your health. 

My goal is to not only advocate for more options but to educate by sharing digestible and helpful information about both conventional and what we call alternative medicines. 

I am deeply passionate about exploring new frontiers in health and wellness, particularly for women, as this reflects my own human experience. Having personally turned to plant-based solutions in certain instances, I understand firsthand the importance of empowering others to invest time in learning about their bodies and discovering new and alternative paths to well-being.

I’m thrilled to be part of the curation team at Microdosing.com, where we blend science, tradition, and practical insights to help our community cultivate balance and well-being.

Whether you’re navigating these challenges yourself or supporting someone who is, I’m here with you.

Take it one microdose at a time,

Stephanie Karzon Abrams, Clin.Pharm. 

_{In Crisis? If you’re having thoughts of self-harm please call 988 or visit 988Lifeline.org. If you’re experiencing a difficult trip, or need help integrating one, consider contacting Fireside Project by calling or texting 62-FIRESIDE or visit firesideproject.org.}